"Super-resolution imaging of chromatin organization in health and disease" with Melike Lakadamyali, University of Pennsylvania (Online Seminar)

Title: Super-resolution imaging of chromatin organization in health and disease

Speaker: Melike Lakadamyali, University of Pennsylvania

Hosted by: Arpita Upadhyaya

Abstract: Human DNA is 2 meters in length and must be packaged into the small space of a cell’s nucleus. New technologies, including super-resolution microscopy, are revealing how the genome is folded and packaged inside intact nuclei. I will present our work on using super-resolution microscopy to visualize and quantify chromatin nano-structure in single cells. I will further talk about how the chromatin nano-structure can be remodeled via chemo-mechanical cues. Finally, I will show that degenerative chemo-mechanical cues during disease can lead to aberrant chromatin nano-structure, potentially impacting cell phenotype.