Research interests: Proteins as dynamic molecular machines at the atomic resolution. Structure, dynamics, and recognition in multi-domain proteins and protein complexes. Intracellular signaling, especially in ubiquitin-mediated pathways. Methodology: Nuclear magnetic resonance (NMR) and relaxation, small-angle X-ray and neutron scattering (SAXS/SANS), molecular dynamics (MD) simulations, and physical and mathematical modeling.